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Dr Jean Delalande, PhD

Jean

Lecturer

Email: j.m.delalande@qmul.ac.uk
Telephone: 020 7882 2394
Website: https://scholar.google.co.uk/citations?user=PHLzkpEAAAAJ&hl=en

Profile

 

I did my PhD at the University of Rennes I  (France) where I studied myogenic bHLH transcription factors, a group of genes acting as master transcriptional regulators of muscular development. I then took up post-doctoral positions at the Royal Free Hospital (UK) with Prof. Geoffrey Goldspink, at the Institute of Child Health (UK) with Dr. Alan Burns and at Emory University (USA) with Dr. Iain Shepherd. I also held a research-associate position at the Huntsman Cancer Institute in salt Lake City (USA).

I joined Queen Mary University London (UK) as a Lecturer in 2014.

 

Summary

We all spend the first 40 minutes of our life as a single cell. The subsequent generation of a complex multicellular organism from this single cell is one of the most fascinating processes in biology. My research interest has been to study the harmonious interplay of signalling ensuring the embryo's peripheral nervous system develops normally. In particular, I have been studying the development of the enteric nervous system (ENS), which controls and regulates gut motility. My research focuses on the behaviour of neural crest cells (the cells which build up the ENS): how they migrate, connect and interact with other cell types in the embryonic gut. Studies of ENS development are of clinical significance since ENS defects result in commonly occurring gut disorders (including Hirschsprung disease, intestinal pseudo-obstruction, and other motility defects) for which new therapies are needed.

Teaching

During my PhD, I was an instructor in animal physiology for biology students at the University of Rennes I (France). I also was an instructor in biology laboratories for medical students at Emory University (USA) teaching genetics, forensic science and developmental biology.

In 2014, I joined Queen Mary University London (UK) as a Lecturer. I am the module lead for metabolism for MBBS year1 and 2 and GEP. I am also the teaching lead for the Centre for immunobiology.


Research

Publications

Vascularisation is not necessary for gut colonisation by enteric neural crest cells. Delalande JM, Natarajan D, Vernay B, Finlay M, Ruhrberg C, Thapar N, Burns AJ. Dev Biol. 2014 Jan 15;385(2):220-9.

The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium.  Marshall TW, Lloyd IE, Delalande JM, N√§thke I, Rosenblatt J. Mol Biol Cell. 2011 Nov;22(21):3962-70

KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Alves MM, Burzynski G, Delalande JM, Osinga J, van der Goot A, Dolga AM, de Graaff E, Brooks AS, Metzger M, Eisel UL, Shepherd I, Eggen BJ, Hofstra RM. Hum Mol Genet. 2010 Sep 15;19(18):3642-51

Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm. Esterberg, R, Delalande, JM, & Fritz, A (2008) Development. 135 (23):3891-901

The receptor tyrosine kinase RET regulates hindgut colonization by sacral neural crest cells. Delalande JM, Barlow AJ, Thomas AJ, Wallace AS, Thapar N, Erickson CA, Burns AJ. Dev Biol. 2008 Jan 1;313(1):279-92

Neural crest cell origin for intrinsic ganglia of the developing chicken lung. Burns AJ & Delalande JM (2005). Dev. Biol. 277: 63-79.

In ovo transplantation of enteric nervous system precursors from vagal to sacral neural crest results in extensive hindgut colonisation. Burns AJ, Delalande JM, Le Douarin NM. Development. 2002 Jun;129(12):2785-96.


View all Jean Marie Delalande's Research Publications at: http://www.researchpublications.qmul.ac.uk

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