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Stem Cells, Regeneration and Cancer

Polycomb group genes and satellite cells in skeletal muscle regeneration
Polycomb group genes and satellite cells in skeletal muscle regeneration

Lead: Professor Silvia Marino

We are a multidisciplinary research group composed of basic scientists and clinical researchers with the common aim to apply knowledge of basic stem cell biology to advance our understanding of human disease.

We study epigenetic mechanisms regulating the biology of normal and neoplastic stem cells. We are investigating the role of deregulated self-renewal mechanisms in initiation and progression of brain tumours. Moreover, we are interested in assessing how fine tuning of the expression of chromatin modifiers, such as the PcG genes, can be exploited to enhance the regenerative function of stem cells in developmental and adult diseases..

Brain Tumour Research Centre of Excellence

The research will focus on glioblastoma multiforme (GBM), the most common and most aggressive malignant brain tumour of adulhood. The aim of the research is to increase our understanding of the cells within the brain from which GBM originates. The team will look at how this particular type of brain tumour develops from normal cells, and which genes and biological functions control its behaviour. By uncovering this essential knowledge, the clinical evaluation of each individual patient can be improved and better and more specific drugs which target the tumour cells can be identified.

Polycomb group genes and satellite cells in skeletal muscle regeneration.

Adult skeletal muscle has a remarkable ability to repair itself after injury as a result of its resident stem cell population, the ‘satellite cells’. We are studying the impact of loss and gain of the PcG gene Bmi1 on the regenerative capacity of the satellite cells.

Mouse models of medulloblastoma.

Novel signalling pathways involved in the metastatic spread of these highly aggressive brain tumours of childhood are being investigated.

 

Current projects in the lab are funded by the MRC, Brain Tumour Research, Barts and The London Charity and NIHR.

Undergraduate


Postgraduate

Prof Marino is the academic lead for the NIHR Integrated Academic Training at QMUL


PhD studentships

Prof Marino is pleased to consider applications from prospective PhD students.


Professional development


Lab experience placements

Prof Marino is pleased to consider applications for prospective lab placements.

Academic staff
Prof. Denise Sheer (Group Lead)

Post-Doc Researchers and Fellows
Dr. Johan Aarum, Dr. Tania Corbett-Jones, Dr. Jennie Jeyapalan, Dr. Sheena Patel, Dr William Ogunkolade

Placement students
Alfred Hill, Isabel Morley

Honorary staff


Administrative staff
Surinder Pal

 

 

News & Announcements

 


Seminars (Genomic Medicine Seminars)

 

Prof. Denise Sheer
d.sheer@qmul.ac.uk This e-mail address is being protected from spambots. You need JavaScript enabled to view it. Tel: +44 (0)20 7882 2595 Fax: +44 (0)20 7882 2180

Mr Surinder Pal
Centre Administrator
s.pal@qmul.ac.uk This e-mail address is being protected from spambots. You need JavaScript enabled to view it. Tel: +44 (0)20 7882 8605 Fax: +44 (0)20 7882 2180

Centre for Neuroscience and Trauma
Blizard Institute
Barts and The London School of Medicine and Dentistry
4 Newark Street
London
E1 2AT

 

Academic staff
Prof Silvia Marino (Group Lead)

Dr Maria Niklison-Chirou (Children with Cancer UK Fellow)

Post-Doctoral Researchers and Fellows

Dr Loredana Guglielmi, Dr Silvia Dibenedetto, Dr Sara Badodi, Dr Claire Vinel

Clinical Research Fellows
Dr Ashirward Merve, Dr Thomas Millner

PhD Researchers
Ms Barbara Ricci

Research Technician
Dr Xinyu Zhang

Administrative staff
Ms Jaya Rajamanje (Centre Manager)

Mr Alan Flynn (NIHR IAT Programme Administrator)

Contact information

Prof. Silvia Marino
s.marino@qmul.ac.uk Tel: +44 (0)20 7882 2585 Fax: +44 (0)20 7882 2180

Dr Xinyu Zhang
xinyu.zhang@qmul.ac.uk Tel: +44 (0)20 7882 2201 Fax: +44 (0)20 7882 2180

Mr Alan Flynn

a.flynn@qmul.ac.uk Tel. +44 (0)20 7882 3365

 

Centre for Genomics and Child Health

Blizard Institute

Barts and The London School of Medicine and Dentistry

4 Newark Street, London E1 2AT

Tel: +44 (0)20 7882 2483

 

 

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