Lead: Professor Silvia Marino
We are a multidisciplinary research group composed of basic scientists and clinical researchers with the common aim to apply knowledge of basic stem cell biology to advance our understanding of human disease.
We study epigenetic mechanisms regulating the biology of normal and neoplastic stem cells. We are investigating the role of deregulated self-renewal mechanisms in initiation and progression of brain tumours. Moreover, we are interested in assessing how fine tuning of the expression of chromatin modifiers, such as the PcG genes, can be exploited to enhance the regenerative function of stem cells in developmental and adult diseases..
Brain Tumour Research Centre of Excellence
The research will focus on glioblastoma multiforme (GBM), the most common and most aggressive malignant brain tumour of adulhood. The aim of the research is to increase our understanding of the cells within the brain from which GBM originates. The team will look at how this particular type of brain tumour develops from normal cells, and which genes and biological functions control its behaviour. By uncovering this essential knowledge, the clinical evaluation of each individual patient can be improved and better and more specific drugs which target the tumour cells can be identified.
Polycomb group genes and satellite cells in skeletal muscle regeneration.
Adult skeletal muscle has a remarkable ability to repair itself after injury as a result of its resident stem cell population, the ‘satellite cells’. We are studying the impact of loss and gain of the PcG gene Bmi1 on the regenerative capacity of the satellite cells.
Mouse models of medulloblastoma.
Novel signalling pathways involved in the metastatic spread of these highly aggressive brain tumours of childhood are being investigated.
Current projects in the lab are funded by the MRC, Brain Tumour Research, Barts and The London Charity and NIHR.
- MSc Neuroscience and Translational Medicine
- MSc Regenerative Medicine
- MSc Molecular Pathology of Tumours (BCI)
Prof Marino is the academic lead for the NIHR Integrated Academic Training at QMUL
Prof Marino is pleased to consider applications from prospective PhD students.
Lab experience placements
Prof Marino is pleased to consider applications for prospective lab placements.
Prof Silvia Marino (Group Lead)
Dr Maria Niklison-Chirou (Children with Cancer UK Fellow)
Post-Doctoral Researchers and Fellows
Dr Loredana Guglielmi, Dr Silvia Dibenedetto, Dr Sara Badodi, Dr Claire Vinel
Clinical Research Fellows
Dr Ashirward Merve, Dr Thomas Millner
Ms Barbara Ricci
Dr Xinyu Zhang
Ms Jaya Rajamanje (Centre Manager)
Mr Alan Flynn (NIHR IAT Programme Administrator)
Prof. Silvia Marino
firstname.lastname@example.org Tel: +44 (0)20 7882 2585 Fax: +44 (0)20 7882 2180
Dr Xinyu Zhang
email@example.com Tel: +44 (0)20 7882 2201 Fax: +44 (0)20 7882 2180
Mr Alan Flynn
firstname.lastname@example.org Tel. +44 (0)20 7882 3365
Centre for Genomics and Child Health
Barts and The London School of Medicine and Dentistry
4 Newark Street, London E1 2AT
Tel: +44 (0)20 7882 2483