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Centre for Genomics and Child Health

The Centre for Genomics and Child Health constitutes a critical mass of clinical and non-clinical scientists whose research encompasses genomics to address the biology of health and human (Mendelian and complex) disease. It has a translatable link to many clinical diseases particularly those important in childhood. Being located in the iconic Blizard Institute the Centre benefits from state of the art research facilities.

In addition to contributing to basic and translational research the Centre has an important role in undergraduate and post graduate training. It also has a strong interface with Barts Health clinical specialties including paediatrics, diabetes, gastroenterology, haematology and pathology. This ensures, where necessary, research is facilitated by appropriately phenotyped biological resource and that scientific discovery has a clear port for translation into patient benefit. It also provides an excellent framework and comprehensive infrastructure for training clinical and basic scientists of the future.

The current research areas/groupings are:

i. Bone marrow failure and related disorders

The principal research interest of Professor Inderjeet Dokal and Professor Tom Vulliamy is bone marrow failure (BMF) focusing on the genetics of the inherited BMF syndromes, particularly dyskeratosis congenita (DC). Their research has highlighted the important role of telomeres in humans and the consequences of telomere dysfunction including dysregulated human development, premature ageing, increased risk of BMF and cancer. Current research is focused on elucidating the biology of the many uncharacterized cases of DC, BMF, familial myelodysplasia/leukaemia  (with Professors Jude Fitzgibbon and Jamie Cavenagh) as well as studies aimed at correction of the cell defect with the long term aim of developing new therapies for this group of patients.

ii. Brain tumours and neural stem cells

Professors Silvia Marino and Denise Sheer have developed a systematic strategy to identify critical genetic, epigenetic and gene expression features in brain tumours. Key discoveries include RAF fusions in pilocytic astrocytomas, microhomology at the RAF fusion breakpoints, MYB abnormalities in certain grade II astrocytomas (Sheer) and the identification and elucidation of the role of PcG group genes in medulloblastoma and high grade glial tumours (Marino). Ongoing studies include exome sequencing, DNA methylation and histone mark profiling with a view of understanding the neural stem cell as cell of origin of brain tumours and identifying novel targets for treatment via studying the basic biology of brain tumours.

iii. Children’s environmental health and respiratory disease

Professor Jonathan Grigg’s environmental research is focused on our local population. The “Exhale” study is measuring changes in lung function and biomarkers of exposure to air pollution in primary school children over a 5 year period–coinciding with the introduction of the London low emission zone. Laboratory studies are assessing the mechanisms underlying the increased vulnerability to pneumococcal pneumonia in children exposed to particulate air pollution. In our NHS patients research is focused on treatment of preschool wheeze, difficult asthma and the prevalence of obstructive breathing in patients with sickle cell disease (Dr Paul Telfer).

iv. Colorectal cancer

The major interest of Professor Andrew Silver and Mr Mohamed Taha is colorectal cancer. This includes the identification of susceptibility genetic variants and modifiers of colorectal cancer (CRC) severity, and use of biomarkers of risk and outcome to facilitate stratified management in the clinic. Current studies are focussed on early onset CRC and the potential mechanistic links between type 2 diabetes and the risk of developing CRC. The genomics approach is also being applied to other types of gastro-intestinal cancers including oesophageal cancer with Professor David Kelsell. In collaboration with Dr James Lindsay the colorectal team have a strong programme of research in inflammatory bowel disease (IBD). This includes the identification of tissue and serum-based biomarkers for early detection of lesions in ulcerative colitis and fibrosis in Crohn’s disease. The group is also investigating the use of specific Histone deacetylase inhibitors for use in IBD control.

v. Developmental alterations in Down syndrome

Identification of molecular pathways altered by trisomy 21, leading to new insights into biology of Down syndrome (DS) is the long term research theme of  Professor Dean Nizetic and Dr Jurgen Groet. This team identified the deregulation of embryonic stem cell fate and a new concept explaining how this de-regulation could be responsible for the increased leukaemia risk in DS children .This team generated the first induced-pluripotency-stem-cells (iPSC) within the Blizard Institute, establishing a unique isogenic DS iPSC model.

vi. Diabetes and obesity

Professor Graham Hitman’s and Dr Elena Bochukova principal research is on genomics (genetic and epigenetic) of diabetes and obesity. They are part of the wider Barts diabetes and obesity research group. The Bochukova group’s main work is the identification of variants linked to human obesity and related measures and their functional relevance to metabolic phenotypes; this work interfaces with Hitman, Finer and van Heel. Prof Hitman together with Sarah Finer (Primary Care and Public Health) research interest is directed to people from South Asia focussing on genomics and prevention strategies in high risk populations. For example one current program includes genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity in South Asians living in Europe or their home countries. This work also has a complementary interface with other investigators in the Centre (Professors Vardhman Rakyan and David van Heel) and that of Primary Care and Public Health (Professors Khan and Thangaratinam). 

vii. Epigenetics

The overall goals of the groups led by Professor Vardhman Rakyan, Doctors Miguel Branco, Ana O’Loghlen and Yung-Yao Lin, are to understand the molecular basis of the non-genetically determined component of mammalian phenotypes and diseases. Within this context the Rakyan group has a particular interest in ‘epialleles'–loci at which the epigenetic state varies as a result of stochastic, genetic and/or environmental influences. Several complementary lines of investigation are pursued to integrate molecular genomics, computational biology, mouse models, and human cohorts to understand the role of epialleles in complex phenotypes and diseases, transgenerational epigenetic inheritance, and environmental epigenomics.

The Branco group is investigating DNA methylation as well as its enzymatic oxidation derivatives (e.g. hydroxymethylation) with a particular interest in the targeting of retrotransposable elements by epigenetic modifiers and how this impacts on the host’s genome. 

The O’Loghlen group is investigating the role of the epigenetic complex PRC1 (Polycomb Repressive Complex 1) in repressing important tumour suppressors such as the INK4a/ARF locus. There is also interest in the function of PRC1 components, in particular the polycomb protein CBX7, in maintaining stem cell pluripotency and inducing cellular differentiation.

viii. Human autoimmune diseases

The principal research interest of Professor David van Heel is human autoimmune diseases (Coeliac disease, type 1 diabetes and Crohn's disease), and the functional consequences of genetic variants on human biology. Significant discoveries have included the identification of 40 new risk variants for Coeliac disease, understanding the overlap between autoimmune diseases, and probing the role of rare variants. Professors David Van Heel and Richard Trembath have been recently awarded a Wellcome Trust Strategic Award to sequence East London populations to identify volunteers carrying homozygous rare loss of function variants (“human knockouts”) and recall them for deep phenotyping, a project that will play a key role in Queen Mary’s proposed new Life Sciences Institute. Professor David van Heel directs the Barts Genome Center; this ensures a comprehensive genomics platform for all investigators in the Centre and Institute wide.

ix. Neonatal medicine

The major emphasis of neonatal research has been the study of determinants of adverse outcomes following extremely preterm birth. This has involved long term collaborations between Professor Kate Costeloe and other institutions: the EPICure studies with Professor Marlow and studies of lung function with Professors Stocks and Dezateux. Other areas include the role of probiotics (Professor Kate Costeloe, Drs Shahid Hussain and Paul Fleming) in prevention of complications of prematurity in collaboration with the Dept of Microbiology in Barts Health, the use of Doppler ultrasound to study the neonatal circulation, particularly in relation to necrotizing enterocolitis (Dr Steve Kempley),  mechanisms of placental transfer of nutrients, retinopathy of prematurity (Drs Shahid Husain, Ajay Sinha) and hypoxic ischaemic encephalopathy (Dr Divyen Shah).

x. Neuromuscular disorders

Professor Marino’s group is interested in the biology of the adult skeletal muscle stem cells and progenitor cells, on the pathways and genes involved in control of their maintenance, proliferation and differentiation, in particular the Polycomb group genes (PcG). We are particularly interested in assessing how fine tuning of the expression of these genes can be exploited to enhance the regenerative function of the skeletal muscle in chronic neuromuscular disorders. The Lin group is investigating the molecular and cellular mechanisms underlying allelic variants of muscular dystrophies, focusing on the key components of the dystrophin-associated glycoprotein complex (DGC) and genetic modifiers of the DGC. Current research strategies have employed cellular reprogramming and genome editing technologies with the long-term aim of developing new therapeutic interventions. Prof Marino and Dr Lin collaborate on a project aiming at applying PcG gene modulation to Duchenne Muscular Dystrophy.

xi. Paediatric infection and immunology

Dr Andrew Prendergast’s group has a focus on the interaction between infection, immunity and malnutrition, particularly in the context of HIV infection. Specifically, his group is investigating the role of microbial translocation, a pathological process that underlies two conditions of global public health importance: childhood malnutrition and HIV infection. Laboratory investigations of the causal pathway linking poor sanitation/hygiene and impaired growth in infancy and the link between the gut microbiota and growth are being explored.

Undergraduate

i. MBBS course. The Centre is responsible for the design and delivery of the Child Health component of the Human Development Module. This is delivered in years 1, 2 and 4. The Child Health Module lead is Dr Steve Kempley.

ii. The Centre is also involved in other parts of the MBBS course through the delivery of PBLs, OSCEs and lectures.

iii. Dr Jurgen Groet and Prof Jo Martin are responsible for organising the Experimental Pathology BSc (15—20 students /year).

iv. The Centre contributes to other BSc courses delivered by the Blizard Institute.

Postgraduate

i. Dr Paul Allen is Director of Graduate Studies for the Blizard Institute (overseeing progress of all PhDs and MDs) and member of committees for PGR students at School and College level.

ii. There are opportunities for PhD and MD research projects within all research areas/groups in the Centre.

iii. The Centre contributes to other postgraduate (MSc) courses delivered by the Blizard Institute. Professor Denise Sheer is module (Neuro-Oncology) lead for MSc in Neuroscience. Dr Jurgen Groet is module (induced pluripotent stem cells and genome engineering) lead for MSc in Regenerative Medicine.

iv. Coordination (Lead, Prof Silvia Marino) of the NIHR Academic Clinical Fellow (ACF) and Clinical Lecturer (CL) programme for QMUL/SMD.

Paul Allen Elena Bochukova Miguel Branco
Reader in Cell Biology Lecturer Senior Lecturer
Kathleen Costeloe Inderjeet Dokal Jonathan Grigg
Professor of Paediatrics Centre Lead, Genomics, Chair of Child Health Professor of Paediatric Respiratory and Environmental Medicine
Jürgen Groet Graham Hitman Shahid Husain
Senior Research Fellow, Blizard UG Education Lead Blizard Institute Director Clinical Senior Lecturer, Paediatrics
Steve Kempley Yung-Yao Lin Rob Lowe
Clinical Senior Lecturer, Paediatrics Non Clinical Lecturer, Cutaneous Lecturer in Computational Biology
Sylvia Marino Joanne Martin Dean Nizetic
Professor of Neuropathology Professor of Pathology, Core Pathology Professor of Cellular & Molecular Biology, Paediatrics
Ana O'Loghlen Andrew Prendergast Vardhman Rakyan
Non Clinical Lecturer, Epigenetics Clinical Senior Lecturer, Paediatrics Professor of Epigenetics, Diabetes
 
Denise Sheer Andy Silver Paul Telfer
Professor of Human Genetics Professor of Cancer Genetics Senior Lecturer
 
David Van Heel Tom Vulliamy  
Professor of Genetics Professor in Molecular Biology  

Postdoc

Surname First name Email
Aarum Johan j.aarum@qmul.ac.uk
Aoife Murray aoife.murray@qmul.ac.uk
Badodi Sarah s.badodi@qmul.ac.uk
Bourke Claire c.bourke@qmul.ac.uk
Carpintero Paula p.carpintero@qmul.ac.uk
Deniz Ozgen o.deniz@qmul.ac.uk
Dibenetto Silvia s.dibenetto@qmul.ac.uk
Frost Jennifer j.frost@qmul.ac.uk
Gibbons Joseph j.gibbons@qmul.ac.uk
Goh Pollyanna p.goh@qmul.ac.uk
Guglielmi Loredana l.guglielmi@qmul.ac.uk
Holland Michele m.holland@qmul.ac.uk
Jeyapalan Jennie j.jeyapalan@qmul.ac.uk
Kim Jihee jihee.kim@qmul.ac.uk
Labora Juan j.a.f.labora@qmul.ac.uk
Miyashita Lisa l.miyashita@qmul.ac.uk
Niklison-Chirou Maria m.niklison-chirou@qmul.ac.uk
Patel Nisha nisha.patel@qmul.ac.uk
Rosser Gabriel g.rosser@qmul.ac.uk
Sacharz Joanna j.sacharz@qmul.ac.uk
Southgate Laura l.southgate@qmul.ac.uk
Suri Reetika r.suri@qmul.ac.uk
Tummala Hemanth h.tummala@qmul.ac.uk
Vinel Claire c.vinel@qmul.ac.uk
Walne Amanda a.walne@qmul.ac.uk

Learning and Outreach Officer

Surname First name Email
Ahende Lizette l.ahenda@qmul.ac.uk
Mosler Gioia g.mosler@qmul.ac.uk

Research Fellow

Surname First name Email
Corbett-Jones Tania t.a.corbett-jones@qmul.ac.uk
Davidson Ateh d.d.ateh@qmul.ac.uk
Lewis Amy a.lewis@qmul.ac.uk
Ogunkolade William b.w.ogunkolade@qmul.ac.uk

Academic Clinical Fellow (ACF)

Surname First name Email
Evans Ceri ceri.evans@qmul.ac.uk
Merve Ashirwad a.merve@qmul.ac.uk
Piper Joe j.piper@qmul.ac.uk
Sturgeon Jonathan j.sturgeon@qmul.ac.uk

Research Delivery Officer, Clinical Research Network

Surname First name Email
Ashida Ken ken.ashida@bartshealth.nhs.uk
Garvey Isabelle i.garvey@qmul.ac.uk
Ono Mutsumi mutsumi.ono@bartshealth.nhs.uk
Samsuddin Salma salma.samsuddin@bartshealth.nhs.uk
Worthington Anne anne.worthington@bartshealth.nhs.uk

Research Technician

Surname First name Email
Ellison Alicia a.ellison@qmul.ac.uk
Zhang Xinyu xinyu.zhang@qmul.ac.uk

Research Assistant

Surname First name Email
Bocket Nick n.bockett@qmul.ac.uk
Cheng Kevin CL K.cheng@qmul.ac.uk
Islam Kamrul k.islam@qmul.ac.uk
Neal Ed e.neal@qmul.ac.uk
Padovan Michelle m.padavon@qmul.ac.uk
Wong Katherine k.wong@qmul.ac.uk

Research Manager

Surname First name Email
Hunt Karen k.a.hunt@qmul.ac.uk

Nurse

Surname First name Email
Openshaw-Lawrence Nicola n.openshaw-lawrence@qmul.ac.uk
Shobhash Jhuree s.jhuree@qmul.ac.uk

Project Manager

Surname First name Email
MacLaughlin Beverley b.maclaughlin@qmul.ac.uk

Senior Diabetes Research Manager

Surname First name Email
Hood Gillian g.hood@qmul.ac.uk

PhD & MD Students

Surname First name Email
Boot James j.r.boot@qmul.ac.uk
Borghesan Michela m.borghesan@qmul.ac.uk
Cardoso Shirleny s.r.cardosa@qmul.ac.uk
Church James j.church@qmul.ac.uk
Danson Amy a.f.danson@qmul.ac.uk
Dumas Anaelle a.a.dumas@qmul.ac.uk
Harris Katherine k.harris@qmul.ac.uk
Hutchinson Richard r.hutchinson@qmul.ac.uk
Lee Koh l.c.koh@qmul.ac.uk
Liu Norrice n.liu@qmul.ac.uk
Millner Thomas t.millner@qmul.ac.uk
Paredes Redondo Amaia a.paredesredondo@qmul.ac.uk
Ricci Barbara b.ricci@qmul.ac.uk
Rozhavskaya Katya e.rozhavskaya@qmul.ac.uk
Thompson Hannah hannah.thompson@qmul.ac.uk
Todd Christopher c.todd@qmul.ac.uk
Whitehouse Abigail a.whitehouse@qmul.ac.uk
Williams Samson s.a.williams@qmul.ac.uk

 

Surname First name Honorary Title Email Location Clinical Specialty /Research interest
Aladangady Narendra Clinical Professor Narendra.Aladangady@homerton.nhs.uk Homerton Neonatal Medicine
Charlesworth Paul Clinical Senior Lecturer paul.charlesworth@bartshealth.nhs.uk Barts Health Paediatric Surgery
Dundas Isobel Non-Clinical Senior Lecturer Isobel.Dundas@bartshealth.nhs.uk Barts Health Paediatric Respiratory
Fleming Paul Clinical Senior Lecturer Paul.Fleming@homerton.nhs.uk Homerton Neonatal Medicine
Gabr Ashraf Clinical Lecturer Ashraf.Gabr@bartshealth.nhs.uk Whipps Cross General Paediatrics
Green Laura Clinical Senior Lecturer laura.green@bartshealth.nhs.uk Barts Health Haematology
Hossain Upal Clinical Senior Lecturer upal.hossain@bartshealth.nhs.uk Whipps Cross Haematology
Kaya Banu Clinical Senior Lecturer Banu.Kaya@bartsheatlh.nhs.uk Barts Health Haematology
Laing Gabrielle Clinical Senior Lecturer Gabrielle.Laing@homerton.nhs.uk Homerton Community Paediatrics
Mahomed Fathima Clinical Senior Lecturer fathima.mahomed@bartshealth.nhs.uk Barts Health General Paediatrics
Malik Maerouf Clinical Senior Lecturer Maerouf.Malik@netscape.net Colchester General Paediatrics
Moodambail Abdul Clinical Senior Lecturer Abdul.Moodambail@bartshealth.nhs.uk Newham General General Paediatrics
Noimark Lee Clinical Senior Lecturer Lee.Noimark@bartshealth.nhs.uk Barts Health General Paediatrics
Nwokoro Chinedu Clinical Senior Lecturer Chinedu.Nwokoro@bartshealth.nhs.uk Barts Health Paediatric Respiratory Medicine
Shah Divyen Clinical Senior Lecturer Divyen.Shah@bartshealth.nhs.uk Barts Health Neonatal Medicine
Sinha Ajay Clinical Senior Lecturer Ajay.Sinha@bartshealth.nhs.uk Barts Health Neonatal Medicine
Trembath Richard Clinical Professor r.trembath@qmul.ac.uk Kings College Medical Genetics
Turner Mark Duncan Clinical Senior Lecturer m.d.turner@qmul.ac.uk Barts Health Endocrinology
Burguillos Miguel Postdoctoral Research Fellow m.burguillos@qmul.ac.uk Blizard Institute Neuroimmunology

 

Centre Lead:                 

Professor Inderjeet Dokal, i.dokal@qmul.ac.uk

Centre Manager:                      

Jaya Rajamanie, 020 7882 2619 j.rajamanie@qmul.ac.uk

Centre Administrators:           

Shirley Dankyi-Larbi, 020 7882 2615  s.dankyi-larbi@qmul.ac.uk

Julia Moreta Diaz, 020 7882 2618  j.moretadiaz@qmul.ac.uk

 
AcronymFull TitleSite Open datePrincipal InvestigatorLead NurseRecruitsTargetRecruitment end
Royal London
Anser Clinical
Investigation
A multi-centre, randomised, controlled, clinical Investigation of a standalone decision support Algorithm for Neonatal Seizure Recognition 24/07/2015 Divyen Shah Nicola  Openshaw- Lawrence  16 30 31/07/2016
Apo Pharma First* The efficacy and safety of Ferriprox® for the treatment of transfusional iron overload in patients with sickle cell disease or other anemias 10/07/2014 Banu Kaya Theresa 2 2 31/05/2018
Apo Pharma First
Extension
Long-term Safety and Efficacy Study of Ferriprox® for the Treatment of Transfusional Iron Overload in Patients with Sickle Cell Diseaseor Other Anemias 30/11/2015 Banu Kaya Theresa 1 1 31/05/2018
Abbvie M11-290* (iras
143053)
A Multicentre, randomised, Double-Blind, Placebo-Controlled Study of the Human Anti-TNF Monoclonal Antibody Adalimumab in paediatric Subjects with Moderate to Severe Ulcerative Colitis 25/02/2015 Nick Croft Maysze 1 4 30/06/2017
Abbvie Extension study
M10-870
A Multi-centre, Open-Label Study of the Human Anti‑TNF Monoclonal Antibody Adalimumab to Evaluate Long-Term Safety and Tolerability of Repeated Administration of Adalimumab in paediatric Subjects with Ulcerative Colitis Who Completed the Study M11-290 12/05/2016 Nick Croft Maysze 1 1 31/12/2018
ACAP Effect of Exposure of Children to Particulate Matter Air Pollution on Airway Macrophages and Dendritic Cells (ACAP) 11/06/2013 Jonathon Grigg /
Abigail
Whitehouse
NA 433 400 Ongoing
ADDRESS 2 An incident and high risk type 1 diabetes cohort- After Diagnosis
Diabetes Research Support System-2
23/03/2012 Graham Hitman Nicolene 23 10 31/12/2017
AstraZeneca Ticragrelor
D5136C00007
HAEM3709*
Multicentre, Open-label, randomised, pharmacokinetic (PK) and pharmacodynamic (PD) dose-ranging Phase II study of ticagrelor followed by a double-blind, randomised, parallel-group, placebo- controlled 4 weeks extension phase in paediatric patients with sickle cell disease 09/12/2014 Banu Kaya Theresa 2 1 28/02/2016
BASIC Understanding the genetic basis and biological pathways underlying critical illness and how they influence outcome in children requiring emergency intensive care 23/10/2015 Naomi Edmonds Kevin 20 70 31/12/2016
Cell Signalling Networks
in IBD
Clarification of Cell Signalling Networks in Inflammatory Bowel
Diiseases
01/03/2014 Protima Amon Harry 102 200  
chiLD EU Orphans Unite: chILD better together – European Management
Platform for Childhood Interstitial Lung Diseases
18/06/2015 Chinedu Nwokoro Ivone 1 1 30/11/2016
CHIPS - HIV Collaborative HIV Paediatric Study: A Cohort Study of HIV Infected
Children in UK and Ireland
01/07/2007 na NA 13 2 30/09/2016
Epilepsy in infancy: relating phenotype to genotype Epilepsy in infancy: relating phenotype to genotype 18/01/2016 Maha Awadalla NA 0 NA 01/01/2017
Europac-2 Antioxidants and Magnesium in chronic pancreatitis: European Registry of Hereditary Pancreatitis and Pancreatic Cancer (EUROPAC) 2 trial to investigate the efficacy of antioxidants and magnesium for the treatment of Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis 03/11/2011 Sandhia Naik Maysze 3 1 30/09/2018
GEM Project A Multidisciplinary Human Study on the Genetic, Environmental and Microbial Interactions that Cause Inflammatory Bowel Disease 08/01/2015 James Lindsay/ Nick Croft Harry 36 150 30/11/2016
GOOS: Genetics of
obesity study
The genetic basis of severe childhood obesity   Caroline Pao     50 30/11/2017
IGNITE A phase III multi---centre randomised, double blind, placebo controlled trial to assess the role of intravenous immunoglobulin in the management
of children with encephalitis
04/05/2016 Anna Riddell Theresa 0 15 31/07/2020
ITP Registry The UK Paediatric ITP Registry: This is a registry for children with acute and chronic immune thrombocytOpenia (ITP) 28/06/2013 Banu Kaya Bessie 17 65 01/04/2026
Merck MK0431A* A Study to Learn if MK0431A (also called JanumetÒ which is a drug made up of Sitagliptin and Metformin) is Safe and Effective in Treating Children with Type 2 Diabetes 16/12/2014 Evelien Gevers Maysze 1 2 03/12/2017
Merck MK0431A Ext A 34-week Follow-up to: MK-0431A in Pediatric Patients with Type 2 Diabetes Mellitus   Evelien Gevers Maysze 0 0 depending on last patient recruited to main study
PANTS-Ext Investigation of the clinical, serological and genetic factors that determine primary non-response, loss of response and adverse drug reactions to Anti-TNF drugs in patients with active luminal Crohn's Disease - EXTENSION 30/01/2015 Nick Croft Harry 7 na NA
PRED4 Predicting serious drug side effects in gastroenterology 04/09/2012 James Lindsay /
Nick Croft
Harry 2 5 31/12/2016
PREDNOS 2 Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study. 28/03/2013 Ami Parikh Harry  2 2 01/10/2016
PRESTO* A prospective double blind randomised controlled study to evaluate the immunological benefits and clinical effects of an elimination diet using an amino acid formula (AAF) with an added pre-probiotic blend in infants with Cow’s Milk Allergy (CMA) 18/12/2013 Lee Noimark Harry 5 5  
PACT Study PACT - Personalised medicine for Asthma ConTrol 17/12/2015 Jonathan Grigg NA 0 4  
PREVAIL (iras 160376) PREVenting infection using Antimicrobial Impregnated Long lines 18/09/2015 Ajay Sinha Maysze 26 60 30/11/2018
Roche Hep B NV25361* PHASE IIIB, randomised, Open-LABEL STUDY OF PEGYLATED INTERFERON ALFA-2A IN COMBINATIONWITH LAMIVUDINE COMPARED WITH UNTREATED CONTROL PATIENTS IN CHILDREN WITH HBEAG-POSITIVE CHRONIC HEPATITIS B IN THE IMMUNE- TOLERANT PHASE 21/01/2015 Sandhia Naik Maysze 0 2 01/02/2023
TORPEDO Trial of Optimal Therapy for Pseudomonas Eradication in Cystic
Fibrosis
21/09/2012 Chinedu Nwokoro Maysze 3 4 30/09/2016
Shire319 Ulcerative
Colitis*
A Phase 3, Multicentre, randomised, Double-blind Study to
Determine
the Safety and Efficacy of MMX Mesalamine/Mesalazine in paediatric
Subjects with Mild to Moderate Ulcerative Colitis, in both Acute and
Maintenance Phases
16/02/2015 Nick Croft Maysze 1 3 03/06/2019
Sucampo A Multicentre, Randomised, Placebo-controlled, Double-blinded Study of the Efficacy, Safety, and Pharmacokinetics of Lubiprostone in Paediatric Subjects Aged ≥ 6 Years to < 18 Years with Functional Constipation 28/01/2015 David Rawat Harry 4 3  
Sucampo extension A Multicentre, Long-term Safety, Efficacy, and Pharmacokinetics
Study of Lubiprostone in Paediatric Subjects Aged ≥ 6 Years to <
18 Years with Functional Constipation
29/05/2015 David Rawat Harry 3 2 30/11/2016
SCAPE - Patient
Satisfaction
A mixed methods study to adapt and pilot a brief questionnaire measure of sickle cell disease patients' satisfaction with hospital care during acute painful episodes. 29/07/2015 Paul Telfer Theresa 10 36 01/08/2016
SCAPE Phase II evaluation of sub lingual fentanyl combined with oral oxycodone for acute pain management in adolescents and adults with acute painful crisis of sickle cell disease 28/08/2015 Paul Telfer Theresa 2 60 01/08/2016
Newham
ADDRESS 2 An incident and high risk type 1 diabetes cohort- After Diagnosis
Diabetes Research Support System-2
28/03/2012 Abdul
Moodambail
Ivone 66 10 31/12/2017
CHIPS - HIV Collaborative HIV Paediatric Study: A Cohort Study of HIV Infected
Children in UK and Ireland
01/07/2007 Susan
Liebeschuetz
NA 14 8 long term
cohort
Detemir Glargine A comparison of the effects of insulin Detemir with insulin Glargine on weight gain in female adolescents and young adults with Type 1 Diabetes (T1D) on a basal bolus regime 16/07/2014 Abdul
Moodambail
Ivone 5 1 31/10/2014
Epilepsy in infancy: relating phenotype to genotype Epilepsy in infancy: relating phenotype to genotype 18/01/2016 John Ho/ Sateesh
Mathew
Ivone 0    
Goos: Genetics of obesity study The genetic basis of severe childhood obesity   Abdul
Moodambail
ivone     30/11/2017
ITP Registry The UK Paediatric ITP Registry: This is a registry for children with acute and chronic immune thrombocytOpenia (ITP) 03/03/2008 Dr Alex Chan/ Nimze Gadong NA 7 NA 01/04/2026
JUMP Type 2 Diabetes in childhood: building a platform for
interventions to prevent the progression to cardiovascular disease
01/06/2010 Abdul
Moodambail
Ivone 11 5 31/03/2017
PREDNOS 2 Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study. 09/05/2013 Rakesh Ravi Ivone 3 1 01/10/2016
PREVAIL (iras 160376) Babies   Imdad Ali Ivone 8 60  
Whipps Cross
ADDRESS 2 An incident and high risk type 1 diabetes cohort- After Diagnosis
Diabetes Research Support System-2
12/03/2012 Paramita Cifelli Waffa 17 10 31/12/2017
Epilepsy in Infancy Epilepsy in infancy: relating phenotype to genotype 18/01/2016 John Ho Waffa 1    
HI-Light Home Interventions and Light Therapy for the Treatment of
Vitiligo
  Anthony Bewley Waffa 3 20 31/10/2016
GOOS: Genetics of obesity study The genetic basis of severe childhood obesity   Dr Cifelli Waffa 8 1-2a
year
30/11/2017
ITP Registry The UK Paediatric ITP Registry: This is a registry for children with acute and chronic immune thrombocytOpenia (ITP) 28/06/2013 Andrea Leigh Waffa 29 NA 01/04/2026
JUMP Type 2 Diabetes in childhood: building a platform for
interventions to prevent the progression to cardiovascular disease
01/09/2011 Paramita Cifelli Waffa 3 5 31/03/2017
LEO PHARMA LP0076-
1017*
Effect of Calcipotriol plus Betamethasone Dipropionate Gel on the
HPA Axis and Calcium Metabolism in Adolescent Subjects (Aged
12 to 16 Years, 11 months) with Scalp and Body Psoriasis
16/07/2014 Anthony Bewley Waffa 3 3 01/12/2016
PREDNOS 2 Short course daily prednisolone therapy at the time of upper respiratory tract infection in children with relapsing steroid sensitive nephrotic syndrome; the PREDNOS 2 study.   Ann Duthie Waffa 2 1 01/10/2016
Transitions from
paediatric to adult services for sickle cell disease (SCD)
Transitions from paediatric to adult services for sickle cell disease
(SCD): a prospective qualitative study examining
young adult patients’ experiences
25/01/2016 Andrea Leigh Waffa 5 10 31/07/2018

 

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