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Stem Cells, Regeneration and Cancer


 

Lead: Professor Silvia Marino

We are a multidisciplinary research group composed of basic scientists and clinical researchers with the common aim to apply knowledge of basic stem cell biology to advance our understanding of human disease.

We study epigenetic mechanisms regulating the biology of normal and neoplastic stem cells. We are investigating the role of deregulated self-renewal mechanisms in initiation and progression of brain tumours. Moreover, we are interested in assessing how fine tuning of the expression of chromatin modifiers, such as the PcG genes, can be exploited to enhance the regenerative function of stem cells in developmental and adult diseases..

 

Professor Marino leads a research programme in the epigenetic regulation of stem cell function during CNS development and brain tumour formation. In particular, she is investigating the role of deregulated self-renewal mechanisms in initiation and progression of brain tumours.

In the context of the Brain Tumour Research Centre of Excellence, the group focuses on glioblastoma multiforme (GBM), the most common and most aggressive malignant brain tumour of adulhood. The aim of the research is to increase our understanding of the cells within the brain from which GBM originates. The team will look at how this particular type of brain tumour develops from normal cells, and which genes and biological functions control its behaviour. By uncovering this essential knowledge, the clinical evaluation of each individual patient can be improved and better and more specific drugs which target the tumour cells can be identified.

In MRC-funded studies, the Marino group is studying the role of chromatin regulation, particularly through the Polycomb group (PcG) genes, in the development of medulloblastoma, the most common malignant brain tumour in children.

Finally, Prof Marino is interested in assessing how fine tuning of the expression of chromatin modifiers, such as the PcG genes, can be exploited to enhance the regenerative function of stem cells in developmental and adult diseases.

Current projects in the lab are funded by Brain Tumour Research, MRC, Barts and The London Charity and NIHR.

Undergraduate


Postgraduate

Prof Marino is the academic lead for the NIHR Integrated Academic Training at QMUL


PhD studentships

Prof Marino is pleased to consider applications from prospective PhD students.


Lab experience placements

Prof Marino is pleased to consider applications for prospective lab placements.

Academic staff
Prof. Denise Sheer (Group Lead)

Post-Doc Researchers and Fellows
Dr. Johan Aarum, Dr. Tania Corbett-Jones, Dr. Jennie Jeyapalan, Dr. Sheena Patel, Dr William Ogunkolade

Placement students
Alfred Hill, Isabel Morley

Honorary staff


Administrative staff
Surinder Pal

 

 

News & Announcements

 


Seminars (Genomic Medicine Seminars)

 

Prof. Denise Sheer
d.sheer@qmul.ac.uk This e-mail address is being protected from spambots. You need JavaScript enabled to view it. Tel: +44 (0)20 7882 2595 Fax: +44 (0)20 7882 2180

Mr Surinder Pal
Centre Administrator
s.pal@qmul.ac.uk This e-mail address is being protected from spambots. You need JavaScript enabled to view it. Tel: +44 (0)20 7882 8605 Fax: +44 (0)20 7882 2180

Centre for Neuroscience and Trauma
Blizard Institute
Barts and The London School of Medicine and Dentistry
4 Newark Street
London
E1 2AT

 

Academic staff

Prof Silvia Marino (Group Lead)

Dr Maria Niklison-Chirou (Children with Cancer UK Fellow)

Post-Doctoral Researchers and Fellows

Dr Claire Vinel, Dr Gabriel Rosser, Dr Loredana Guglielmi, Dr Sara Badodi, Dr Veronica Freire Beneitez

Clinical Research Fellows

Dr Ashirward Merve, Dr Peter Hall, Dr Thomas Millner

PhD Researchers

Ms Anaelle Dumas, Ms Barbara Ricci, Mr James Boot

Research Technician

Dr Xinyu Zhang

Administrative staff

Ms Jayanthi Rajamanje (centre administrator)

Ms Nancy Schumann (NIHR IAT Programme administrator)

Contact information

Prof. Silvia Marino

s.marino@qmul.ac.uk  Tel: +44 (0)20 7882 2585 Fax: +44 (0)20 7882 2180

Dr Xinyu Zhang

xinyu.zhang@qmul.ac.uk Tel: +44 (0)20 7882 2201 Fax: +44 (0)20 7882 2180

Ms Nancy Schumann

iatadmin@qmul.ac.uk Tel. +44 (0)20 7882 3365

 

Centre for Genomics and Child Health

Blizard Institute

Barts and The London School of Medicine and Dentistry

4 Newark Street, London E1 2AT

Tel: +44 (0)20 7882 2483

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