Our major research focus concerns understanding how epigenetic mechanisms mediate interactions between the genome and environment. As illustrative examples, my laboratory works on three emerging model organisms: the honey bee (Apis mellifera), the zebra finch (Taeniopygia guttata) and the single cell eukaryote Tetrahymena thermophila.
ResearchDickman, M. J., Kucharski, R., Maleszka, R. & Hurd, P. J. (2013) Extensive histone post-translational modification in the honey bee. Insect Biochem. Mol. Biol. 43, 125-137
Hurd, P. J. (2010) The Era of Epigenetics. Brief. Funct. Genomics, 9, 425-428.
Hurd, P. J., Bannister, A. J., Halls, K., Dawson, M. A., Vermeulen, M., Olsen, J. V., Ismail, H., Somers, J., Mann, M., Owen-Hughes, T., Gout, I. & Kouzarides, T. (2009) Phosphorylation of histone H3 Thr-45 is linked to apoptosis. J. Biol. Chem., 284, 16575-16583.
Hurd P. J.*, Fuks, F*., Deplus R. & Kouzarides, T. (2003) The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res., 31, 2305-2312.
Hurd, P. J.*, Fuks, F.*, Wolf, D., Nan, X., Bird, A. P. & Kouzarides, T. (2003) The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J. Biol. Chem., 278, 4035-4040.
Group MembersMarek Wojciechowski (Postdoc)
Danyal Conn (Postdoc)
Daniel Condliffe (PhD)