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Blizard Institute

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Branco Lab

Our group’s research focuses on the epigenetic regulation of transposable elements and its impact on genome function. We are studying how epigenetic mechanisms are involved in both silencing of mobile elements and in the co-adoption of transposons for the benefit of the host.
 

Research

de la Rica L, Deniz O, Cheng KC, Todd CD, Cruz C, Houseley J, Branco MR (2016) “TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells”, Genome Biology, 17:234

de la Rica L, Stanley JS, Branco MR (2016) “Profiling DNA methylation and hydroxymethylation at retrotransposable elements”, Methods Mol Biol, 1400:387-401

Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W (2016) "Maternal DNA methylation regulates early trophoblast development", Developmental Cell, 36(2): 152-63

Booth MJ*, Branco MR*, Ficz G, Oxley D, Krueger F, Reik W, Balasubramanian S (2012) “Quantitative sequencing of 5-methylcytosine and 5-hyroxymethylcytosine at single-base resolution”, Science, 336(6083): 934-7

Ficz G*, Branco MR*, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S, Reik W (2011) “Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation”, Nature, 473(7347): 398-402

*equal contribution

Group Members

Ozgen Deniz (Postdoc)
Jennifer Frost (Postdoc)
Christopher Todd (PhD student)
Ekaterina Rozhavskaya (PhD student)
Keving Cheng (Research Assistant)

Funders

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